Gene:
KCNJ5
potassium inwardly-rectifying channel, subfamily J, member 5

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  CIR; GIRK4; KATP1; Kir3.4; LQT13
PharmGKB Accession Id: PA216

Details

Cytogenetic Location: chr11 : q24.3 - q24.3
GP mRNA Boundary: chr11 : 128761313 - 128787964
GP Gene Boundary: chr11 : 128751313 - 128790964
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Antiarrhythmic Pathway, Pharmacodynamics
    Pharmacodynamic pathway of antiarrhythmic drugs in a stylized cardiac myocyte.

External Pathways

Links to non-PharmGKB pathways.

PharmGKB contains no links to external pathways for this gene. To report a pathway, click here.

Publications related to KCNJ5: 3

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Exome Sequencing Implicates an Increased Burden of Rare Potassium Channel Variants in the Risk of Drug Induced Long QT Syndrome. Journal of the American College of Cardiology. 2014. Weeke Peter, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Drug-induced long QT syndrome. Pharmacological reviews. 2010. Kannankeril Prince, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins. Nature. 1995. Krapivinsky G, et al. PubMed

LinkOuts

Entrez Gene:
3762
OMIM:
600734
UCSC Genome Browser:
NM_000890
RefSeq RNA:
NM_000890
RefSeq Protein:
NP_000881
RefSeq DNA:
AC_000054
AC_000143
NC_000011
NG_023406
NT_033899
NW_001838044
NW_925173
UniProtKB:
B2R744_HUMAN (B2R744)
IRK5_HUMAN (P48544)
Ensembl:
ENSG00000120457
GenAtlas:
KCNJ5
GeneCard:
KCNJ5
MutDB:
KCNJ5
ALFRED:
LO060205N
HuGE:
KCNJ5
Comparative Toxicogenomics Database:
3762
ModBase:
P48544
HumanCyc Gene:
HS04403
IUPHAR Receptor:
Kir3.4 (437)
HGNC:
6266

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