Gene:
RAC1
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  Rac-1; TC-25; p21-Rac1
PharmGKB Accession Id: PA34162

Details

Cytogenetic Location: chr7 : p22.1 - p22.1
GP mRNA Boundary: chr7 : 6414126 - 6443598
GP Gene Boundary: chr7 : 6404126 - 6446598
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Bisphosphonate Pathway, Pharmacodynamics
    Representation of genes involved in bisphosphonates' effects in osteoclasts.

External Pathways

Links to non-PharmGKB pathways.

  1. a6b1 and a6b4 Integrin signaling - (Pathway Interaction Database NCI-Nature Curated)
  2. agrin in postsynaptic differentiation - (BioCarta via Pathway Interaction Database)
  3. Angiopoietin receptor Tie2-mediated signaling - (Pathway Interaction Database NCI-Nature Curated)
  4. angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling - (BioCarta via Pathway Interaction Database)
  5. Arf1 pathway - (Pathway Interaction Database NCI-Nature Curated)
  6. Arf6 downstream pathway - (Pathway Interaction Database NCI-Nature Curated)
  7. bcr signaling pathway - (BioCarta via Pathway Interaction Database)
  8. BCR signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  9. Class I PI3K signaling events - (Pathway Interaction Database NCI-Nature Curated)
  10. E-cadherin signaling in keratinocytes - (Pathway Interaction Database NCI-Nature Curated)
  11. E-cadherin signaling in the nascent adherens junction - (Pathway Interaction Database NCI-Nature Curated)
  12. Endothelins - (Pathway Interaction Database NCI-Nature Curated)
  13. EPHA2 forward signaling - (Pathway Interaction Database NCI-Nature Curated)
  14. EPHB forward signaling - (Pathway Interaction Database NCI-Nature Curated)
  15. Ephrin B reverse signaling - (Pathway Interaction Database NCI-Nature Curated)
  16. fmlp induced chemokine gene expression in hmc-1 cells - (BioCarta via Pathway Interaction Database)
  17. G alpha 12 cascade - (Reactome via Pathway Interaction Database)
  18. how does salmonella hijack a cell - (BioCarta via Pathway Interaction Database)
  19. IL2 signaling events mediated by PI3K - (Pathway Interaction Database NCI-Nature Curated)
  20. IL6-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  21. influence of ras and rho proteins on g1 to s transition - (BioCarta via Pathway Interaction Database)
  22. Integrins in angiogenesis - (Pathway Interaction Database NCI-Nature Curated)
  23. links between pyk2 and map kinases - (BioCarta via Pathway Interaction Database)
  24. Lissencephaly gene (LIS1) in neuronal migration and development - (Pathway Interaction Database NCI-Nature Curated)
  25. LPA receptor mediated events - (Pathway Interaction Database NCI-Nature Curated)
  26. map kinase inactivation of smrt corepressor - (BioCarta via Pathway Interaction Database)
  27. mapkinase signaling pathway - (BioCarta via Pathway Interaction Database)
  28. mcalpain and friends in cell motility - (BioCarta via Pathway Interaction Database)
  29. N-cadherin signaling events - (Pathway Interaction Database NCI-Nature Curated)
  30. Nectin adhesion pathway - (Pathway Interaction Database NCI-Nature Curated)
  31. Nef and signal transduction - (Reactome via Pathway Interaction Database)
  32. Neurotrophic factor-mediated Trk receptor signaling - (Pathway Interaction Database NCI-Nature Curated)
  33. Nongenotropic Androgen signaling - (Pathway Interaction Database NCI-Nature Curated)
  34. Osteopontin-mediated events - (Pathway Interaction Database NCI-Nature Curated)
  35. p38 mapk signaling pathway - (BioCarta via Pathway Interaction Database)
  36. p38 MAPK signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  37. p75(NTR)-mediated signaling - (Pathway Interaction Database NCI-Nature Curated)
  38. Paxillin-dependent events mediated by a4b1 - (Pathway Interaction Database NCI-Nature Curated)
  39. Paxillin-independent events mediated by a4b1 and a4b7 - (Pathway Interaction Database NCI-Nature Curated)
  40. PDGFR-beta signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  41. phosphoinositides and their downstream targets - (BioCarta via Pathway Interaction Database)
  42. phospholipids as signalling intermediaries - (BioCarta via Pathway Interaction Database)
  43. Proteinase activated receptor G alpha (12/13) cascade - (Reactome via Pathway Interaction Database)
  44. rac1 cell motility signaling pathway - (BioCarta via Pathway Interaction Database)
  45. ras signaling pathway - (BioCarta via Pathway Interaction Database)
  46. ras-independent pathway in nk cell-mediated cytotoxicity - (BioCarta via Pathway Interaction Database)
  47. Regulation of p38-alpha and p38-beta - (Pathway Interaction Database NCI-Nature Curated)
  48. role of mal in rho-mediated activation of srf - (BioCarta via Pathway Interaction Database)
  49. role of pi3k subunit p85 in regulation of actin organization and cell migration - (BioCarta via Pathway Interaction Database)
  50. S1P1 pathway - (Pathway Interaction Database NCI-Nature Curated)
  51. S1P2 pathway - (Pathway Interaction Database NCI-Nature Curated)
  52. S1P3 pathway - (Pathway Interaction Database NCI-Nature Curated)
  53. Signaling events mediated by PRL - (Pathway Interaction Database NCI-Nature Curated)
  54. Signaling events mediated by VEGFR1 and VEGFR2 - (Pathway Interaction Database NCI-Nature Curated)
  55. Signaling events regulated by Ret tyrosine kinase - (Pathway Interaction Database NCI-Nature Curated)
  56. Syndecan-4-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  57. t cell receptor signaling pathway - (BioCarta via Pathway Interaction Database)
  58. Thromboxane A2 receptor signaling - (Pathway Interaction Database NCI-Nature Curated)
  59. tumor suppressor arf inhibits ribosomal biogenesis - (BioCarta via Pathway Interaction Database)
  60. ucalpain and friends in cell spread - (BioCarta via Pathway Interaction Database)
  61. y branching of actin filaments - (BioCarta via Pathway Interaction Database)

Publications related to RAC1: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins. Journal of immunology (Baltimore, Md. : 1950). 2006. Poppe Daniela, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes. The Journal of clinical investigation. 2003. Tiede Imke, et al. PubMed

LinkOuts

Entrez Gene:
5879
OMIM:
602048
UCSC Genome Browser:
NM_006908
RefSeq RNA:
NM_006908
NM_018890
RefSeq Protein:
NP_008839
NP_061485
RefSeq DNA:
AC_000050
AC_000068
AC_000139
NC_000007
NT_007819
NT_079592
NW_001839003
NW_923217
HuGE:
RAC1
Comparative Toxicogenomics Database:
5879
ModBase:
P63000
HumanCyc Gene:
HS06134
HGNC:
9801

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