Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation by Darbar Dawood, Motsinger Alison A, Ritchie Marylyn D, Gainer James V, Roden Dan M in Heart rhythm : the official journal of the Heart Rhythm Society (2007). PubMed

Abstract

The angiotensin-converting enzyme (ACE) deletion allele, ACE D, is associated with increased ACE activity and adverse outcomes in cardiovascular disease. Although activation of the renin-angiotensin-aldosterone system (RAAS) now appears to play a role in the pathophysiology of atrial fibrillation (AF), it remains to be determined if ACE genotype impacts response to conventional AAD therapy in patients with AF.

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