Chemical PA446876

PharmGKB clinical annotations provide information about variant-drug pairs based primarily on variant annotations and incorporating variant-specific prescribing guidance from clinical guidelines and FDA-approved drug labels, when available. Curators manually review annotations and create genotype-based summaries describing the phenotypic impact of the variant. Each clinical annotation is assigned a Level of Evidence, which is generally informed by the clinical annotation's score.

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.