lamotrigine

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Literature

The publications shown below are associated with this chemical in PharmGKB based on (1) literature annotations, (2) variant annotations, (3) VIP summaries, or (4) pathways.

    92 items
    Literature
    Association of Lamotrigine Plasma Concentrations With Efficacy and Toxicity in Patients With Epilepsy: A Retrospective Study.
    Therapeutic drug monitoring. 2024. Lee Ze-Ning, van Nuland Merel, Bognàr Tim, Leijten Frans S S and van der Elst Kim C M.
    PGx Paper Type: Methods
    Pediatric
    Literature
    Population Pharmacokinetics of Lamotrigine and Its N2-Glucuronide Metabolite in Chinese Patients With Epilepsy.
    Therapeutic drug monitoring. 2024. Yang Hua, Zhang Dongjie, Wei Shifeng, Zhao Zhigang and Mei Shenghui.
    PGx Paper Type: Methods
    Pediatric
    Literature
    Influence of UGT2B7, UGT1A4 and ABCG2 Polymorphisms on the Pharmacokinetics and Therapeutic Efficacy of Lamotrigine in Patients with Epilepsy.
    European journal of drug metabolism and pharmacokinetics. 2024. Yang Jing, Wang Jinxingyi, Ning Lijie, Wu Changsong, Liu Yang, Xia Jie, Guan Yanping, Liu Qian and Zheng Jianghuan.
    Pediatric
    Literature
    Unraveling the genetic link: an umbrella review on HLA-B*15:02 and antiepileptic drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.
    Pharmacogenetics and genomics. 2024. Tham Kar Mun, Yek Jacklyn Jia Lin and Liu Christopher Wei Yang.
    PGx Paper Type: Review
    Literature
    Exploring the impact of pharmacogenetics on personalized medicine: A systematic review.
    Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria. 2024. Amaro-Álvarez Laura, Cordero-Ramos Jaime and Calleja-Hernández Miguel Ángel.
    PGx Paper Type: Implementation, Review
    Literature
    Impact of Pharmacogenomics on Pediatric Psychotropic Medication Prescribing in an Ambulatory Care Setting.
    Journal of child and adolescent psychopharmacology. 2024. Tonti Erica, Lee Yee Ming, Gruenke Nathan, Ferren Janie and Stutzman Danielle L.
    PGx Paper Type: Implementation, Phenoconversion
    Pediatric
    Literature
    Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries.
    Archives of toxicology. 2024. Medina-Cáliz Inmaculada, Sanabria-Cabrera Judith, Villanueva-Paz Marina, Aukštikalnė Lauryna, Stephens Camilla, Robles-Díaz Mercedes, Pinazo-Bandera José M, García-Cortes Miren, Conde Isabel, Soriano German, Bessone Fernando, Hernandez Nelia, Nunes Vinicius, Paraná Raymundo, Lucena M Isabel, Andrade Raúl J, Niu Hao and Alvarez-Alvarez Ismael.
    Literature
    Stevens-Johnson syndrome with overlapping features of DRESS syndrome: A report of two cases.
    SAGE open medical case reports. 2024. Chin Laura D, MacGillivary Michael L, Purdy Kerri S and Kirshen Carly.
    Literature
    Avoiding severe drug hypersensitivity reactions: a case for HLA genotyping for at-risk patients.
    The Medical journal of Australia. 2023. Stojanova Jana, Day Richard O and Suthers Graeme.
    PGx Paper Type: Implementation, Population Frequency, Commentary
    Literature
    Effect of UGT1A4, UGT2B7, UGT2B15, UGT2B17 and ABC1B polymorphisms on lamotrigine metabolism in Danish patients.
    Epilepsy research. 2022. Petrenaite Vaiva, Öhman Inger, Jantzen Frederik Peter Thal and Ekström Lena.
    Literature
    Acute liver failure associated with lamotrigine in children with epilepsy: A report of two cases and thoughts on pharmacogenomics.
    Epilepsy & behavior reports. 2022. Deng Jie, Fu Zheng-Ran, Wang Long, Liu Jun, Chen Chun-Hong, Fang Fang and Wang Xiao-Ling.
    Literature
    Publication bias in pharmacogenetics of adverse reaction to antiseizure drugs: An umbrella review and a meta-epidemiological study.
    PloS one. 2022. Bally S, Cottin J, Gagnieu M C, Lega J C, Verstuyft C, Rheims S, Lesca G, Cucherat M and Grenet Guillaume.
    PGx Paper Type: Review, Methods
    Literature
    Spectrum of cutaneous adverse reactions to aromatic antiepileptic drugs and human leukocyte antigen genotypes in Thai patients and meta-analysis.
    The pharmacogenomics journal. 2021. Sukasem Chonlaphat, Sririttha Suthida, Chaichan Chonlawat, Nakkrut Thapanat, Satapornpong Patompong, Jaruthamsophon Kanoot, Jantararoungtong Thawinee, Koomdee Napatrupron, Medhasi Sadeep, Oo-Puthinan Sarawut, Rerkpattanapipat Ticha, Klaewsongkram Jettanong, Rerknimitr Pawinee, Tuchinda Papapit, Chularojanamontri Leena, Tovanabutra Napatra, Suvannang Naravut, Rungrotmongkol Thanyada, Saokaew Surasak, Aekplakorn Wichai and Puangpetch Apichaya.
    Literature
    Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants.
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 2021. Eap C B, Gründer G, Baumann P, Ansermot N, Conca A, Corruble E, Crettol S, Dahl M L, de Leon J, Greiner C, Howes O, Kim E, Lanzenberger R, Meyer J H, Moessner R, Mulder H, Müller D J, Reis M, Riederer P, Ruhe H G, Spigset O, Spina E, Stegman B, Steimer W, Stingl J, Suzen S, Uchida H, Unterecker S, Vandenberghe F and Hiemke C.
    Literature
    Developing a gene panel for pharmacoresistant epilepsy: a review of epilepsy pharmacogenetics.
    Pharmacogenomics. 2021. Rodriguez-Acevedo Astrid J, Gordon Louisa G, Waddell Nicola, Hollway Georgina and Vadlamudi Lata.
    Literature
    Influence of genetic variants and antiepileptic drug co-treatment on lamotrigine plasma concentration in Mexican Mestizo patients with epilepsy.
    The pharmacogenomics journal. 2020. Ortega-Vázquez Alberto, Fricke-Galindo Ingrid, Dorado Pedro, Jung-Cook Helgi, Martínez-Juárez Iris E, Monroy-Jaramillo Nancy, Rojas-Tomé Irma S, Peñas-Lledó Eva, Llerena Adrián and López-López Marisol.
    Pediatric
    Literature
    Pharmacoresponse in genetic generalized epilepsy: a genome-wide association study.
    Pharmacogenomics. 2020. Wolking Stefan, Schulz Herbert, Nies Anne T, McCormack Mark, Schaeffeler Elke, Auce Pauls, Avbersek Andreja, Becker Felicitas, Klein Karl M, Krenn Martin, Møller Rikke S, Nikanorova Marina, Weckhuysen Sarah, Consortium EpiPGx, Cavalleri Gianpiero L, Delanty Norman, Depondt Chantal, Johnson Michael R, Koeleman Bobby Pc, Kunz Wolfram S, Marson Anthony G, Sander Josemir W, Sills Graeme J, Striano Pasquale, Zara Federico, Zimprich Fritz, Weber Yvonne G, Krause Roland, Sisodiya Sanjay, Schwab Matthias, Sander Thomas and Lerche Holger.
    Pediatric
    Literature
    Pharmacogenetic profile and major depressive and/or bipolar disorder treatment: a retrospective, cross-sectional study.
    Pharmacogenomics. 2018. Tonozzi Theresa R, Braunstein Glenn D, Kammesheidt Anja, Curran Chris, Golshan Shahrokh and Kelsoe John.
    Literature
    Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.
    Neurology. 2018. McCormack Mark, Gui Hongsheng, Ingason Andrés, Speed Doug, Wright Galen E B, Zhang Eunice J, Secolin Rodrigo, Yasuda Clarissa, Kwok Maxwell, Wolking Stefan, Becker Felicitas, Rau Sarah, Avbersek Andreja, Heggeli Kristin, Leu Costin, Depondt Chantal, Sills Graeme J, Marson Anthony G, Auce Pauls, Brodie Martin J, Francis Ben, Johnson Michael R, Koeleman Bobby P C, Striano Pasquale, Coppola Antonietta, Zara Federico, Kunz Wolfram S, Sander Josemir W, Lerche Holger, Klein Karl Martin, Weckhuysen Sarah, Krenn Martin, Gudmundsson Lárus J, Stefánsson Kári, Krause Roland, Shear Neil, Ross Colin J D, Delanty Norman, EPIGEN Consortium;, Pirmohamed Munir, Carleton Bruce C, Canadian Pharmacogenomics Network for Drug Safety;, Cendes Fernando, Lopes-Cendes Iscia, Liao Wei-Ping, O'Brien Terence J, Sisodiya Sanjay M, EpiPGX Consortium;, Cherny Stacey, Kwan Patrick, Baum Larry, International League Against Epilepsy Consortium on Complex Epilepsies; and Cavalleri Gianpiero L.
    Literature
    HLA-associated drug hypersensitivity and the prediction of adverse drug reactions.
    Pharmacogenomics. 2017. Negrini Simone and Becquemont Laurent.
    Literature
    The association of SCN1A p.Thr1067Ala polymorphism with epilepsy risk and the response to antiepileptic drugs in Slovenian children and adolescents with epilepsy.
    Seizure. 2017. Bertok Sara, Dolžan Vita, Goričar Katja, Podkrajšek Katarina Trebušak, Battelino Tadej and Rener-Primec Zvonka.
    Pediatric
    Literature
    Pharmacogenomics of off-target adverse drug reactions.
    British journal of clinical pharmacology. 2017. Garon Sarah L, Pavlos Rebecca K, White Katie D, Brown Nancy J, Stone Cosby A and Phillips Elizabeth J.
    Literature
    Serum protein binding of 25 antiepileptic drugs in a routine clinical setting: A comparison of free non-protein-bound concentrations.
    Epilepsia. 2017. Patsalos Philip N, Zugman Miguel, Lake Charlotte, James Anthony, Ratnaraj Neville and Sander Josemir W.
    Literature
    HLA-A*24:02 as a common risk factor for antiepileptic drug-induced cutaneous adverse reactions.
    Neurology. 2017. Shi Yi-Wu, Min Fu-Li, Zhou Dong, Qin Bin, Wang Juan, Hu Fa-Yun, Cheung Ying-Kit, Zhou Jin-Hua, Hu Xiang-Shu, Zhou Jue-Qian, Zhou Lie-Min, Zheng Zhong-Zheng, Pan Jie, He Na, Liu Zhi-Sheng, Hou Yun-Qi, Lim Kheng-Seang, Ou Yang-Mei, Hui-Ping Khor Amy, Ng Ching-Ching, Mao Bi-Jun, Liu Xiao-Rong, Li Bing-Mei, Kuan Yao-Yun, Yi Yong-Hong, He Xue-Lian, Deng Xiao-Yan, Su Tao, Kwan Patrick and Liao Wei-Ping.
    Pediatric
    Literature
    Influence of genetic variants of CYP2D6, CYP2C9, CYP2C19 and CYP3A4 on antiepileptic drug metabolism in pediatric patients with refractory epilepsy.
    Pharmacological reports : PR. 2017. López-García Miguel A, Feria-Romero Iris A, Serrano Héctor, Rayo-Mares Darío, Fagiolino Pietro, Vázquez Marta, Escamilla-Núñez Consuelo, Grijalva Israel, Escalante-Santiago David and Orozco-Suarez Sandra.
    Pediatric
    Literature
    Pharmacogenetic and case-control study on potassium channel related gene variants and genetic generalized epilepsy.
    Medicine. 2017. Qu Jian, Lu Shao-Hua, Lu Zhi-Li, Xu Ping, Xiang Da-Xiong and Qu Qiang.
    Pediatric
    Literature
    Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.
    Annals of neurology. 2017. Glauser Tracy A, Holland Katherine, O'Brien Valerie P, Keddache Mehdi, Martin Lisa J, Clark Peggy O, Cnaan Avital, Dlugos Dennis, Hirtz Deborah G, Shinnar Shlomo, Grabowski Gregory and Childhood Absence Epilepsy Study Group.
    Pediatric
    Literature
    No association between non-bullous skin reactions from lamotrigine and heterozygosity of UGT1A4 genetic variants *2(P24T) or *3(L48V) in Norwegian patients.
    Seizure. 2017. Shirzadi Maryam, Reimers Arne, Helde Grethe, Sjursen Wenche and Brodtkorb Eylert.
    Pediatric
    Literature
    Significant HLA class I type associations with aromatic antiepileptic drug (AED)-induced SJS/TEN are different from those found for the same AED-induced DRESS in the Spanish population.
    Pharmacological research. 2017. Ramírez Elena, Bellón Teresa, Tong Hoi Y, Borobia Alberto M, de Abajo Francisco J, Lerma Victoria, Moreno Hidalgo Miguel A, Castañer José L, Cabañas Rosario, Fiandor Ana, González-Ramos Jessica, Herranz Pedro, Cachafeiro Lucía, González-Herrada Carlos, González Olga, Aramburu José A, Laosa Olga, Hernández Rafael, Carcas Antonio J and Frías Jesús.
    Pediatric
    Literature
    Association of HLA-A and HLA-B Alleles with Lamotrigine-Induced Cutaneous Adverse Drug Reactions in the Thai Population.
    Frontiers in pharmacology. 2017. Koomdee Napatrupron, Pratoomwun Jirawat, Jantararoungtong Thawinee, Theeramoke Voralaksana, Tassaneeyakul Wichittra, Klaewsongkram Jettanong, Rerkpattanapipat Ticha, Santon Siwalee, Puangpetch Apichaya, Intusoma Utcharee, Tempark Therdpong, Deesudchit Tayard, Satapornpong Patompong, Visudtibhan Anannit and Sukasem Chonlaphat.
    Literature
    Allele and genotype frequencies of genes relevant to anti-epileptic drug therapy in Mexican-Mestizo healthy volunteers.
    Pharmacogenomics. 2016. Fricke-Galindo Ingrid, Ortega-Vázquez Alberto, Monroy-Jaramillo Nancy, Dorado Pedro, Jung-Cook Helgi, Peñas-Lledó Eva, LLerena Adrián and López-López Marisol.
    Literature
    Specific OCT1 and ABCG2 polymorphisms are associated with Lamotrigine concentrations in Chinese patients with epilepsy.
    Epilepsy research. 2016. Shen Chun-Hong, Zhang Yin-Xi, Lu Ru-Yi, Jin Bo, Wang Shan, Liu Zhi-Rong, Tang Ye-Lei and Ding Mei-Ping.
    Literature
    Effectiveness of antiepileptic therapy in patients with PCDH19 mutations.
    Seizure. 2016. Lotte Jan, Bast Thomas, Borusiak Peter, Coppola Antonietta, Cross J Helen, Dimova Petia, Fogarasi Andras, Graneß Irene, Guerrini Renzo, Hjalgrim Helle, Keimer Reinhard, Korff Christian M, Kurlemann Gerhard, Leiz Steffen, Linder-Lucht Michaela, Loddenkemper Tobias, Makowski Christine, Mühe Christian, Nicolai Joost, Nikanorova Marina, Pellacani Simona, Philip Sunny, Ruf Susanne, Sánchez Fernández Iván, Schlachter Kurt, Striano Pasquale, Sukhudyan Biayna, Valcheva Deyana, Vermeulen R Jeroen, Weisbrod Tanja, Wilken Bernd, Wolf Philipp and Kluger Gerhard.
    Pediatric
    Literature
    HLA Allele Frequencies in 5802 Koreans: Varied Allele Types Associated with SJS/TEN According to Culprit Drugs.
    Yonsei medical journal. 2016. Park Hye Jung, Kim Young Joo, Kim Dong Hyun, Kim Junho, Park Kyung Hee, Park Jung Won and Lee Jae Hyun.
    Literature
    Stevens-Johnson syndrome and toxic epidermal necrolysis: an update on pharmacogenetics studies in drug-induced severe skin reaction.
    Pharmacogenomics. 2015. Rufini Sara, Ciccacci Cinzia, Politi Cristina, Giardina Emiliano, Novelli Giuseppe and Borgiani Paola.
    Literature
    The antiepileptic drug lamotrigine is a substrate of mouse and human breast cancer resistance protein (ABCG2).
    Neuropharmacology. 2015. Römermann Kerstin, Helmer Renate and Löscher Wolfgang.
    Literature
    Modified Atkins diet may reduce serum concentrations of antiepileptic drugs.
    Acta neurologica Scandinavica. 2015. Kverneland M, Taubøll E, Selmer K K, Iversen P O and Nakken K O.
    Literature
    Clinical features of and genetic predisposition to drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a single Korean tertiary institution patients-investigating the relation between the HLA -B*4403 allele and lamotrigine.
    European journal of clinical pharmacology. 2015. Park Hye Jung, Kim Sung Ryeol, Leem Dong Woo, Moon Il Joo, Koh Beom Seok, Park Kyung Hee, Park Jung-Won and Lee Jae-Hyun.
    Literature
    T cell-mediated hypersensitivity reactions to drugs.
    Annual review of medicine. 2015. Pavlos Rebecca, Mallal Simon, Ostrov David, Buus Soren, Metushi Imir, Peters Bjoern and Phillips Elizabeth.
    Literature
    Association between HLA-B*15:02 allele and antiepileptic drug-induced severe cutaneous reactions in Hong Kong Chinese: a population-based study.
    Hong Kong medical journal = Xianggang yi xue za zhi. 2014. Kwan P K L, Ng M H L and Lo S V.
    Pediatric
    Literature
    Stevens-Johnson Syndrome triggered by a combination of clobazam, lamotrigine and valproic acid in a 7-year-old child.
    Annals of burns and fire disasters. 2014. Yapici A K, Fidanci M K, Kilic S, Balamtekin N, Mutluay Arslan M, Yavuz S T and Kalman S.
    Literature
    Pharmacogenetics of antiepileptic drug-induced hypersensitivity.
    Pharmacogenomics. 2014. Bloch Katarzyna M, Sills Graeme J, Pirmohamed Munir and Alfirevic Ana.
    Literature
    Properties of human brain sodium channel alpha-subunits expressed in HEK293 cells and their modulation by carbamazepine, phenytoin and lamotrigine.
    British journal of pharmacology. 2014. Qiao Xin, Sun Guangchun, Clare Jeffrey J, Werkman Taco R and Wadman Wytse J.
    Literature
    HLA-A*02:01:01/-B*35:01:01/-C*04:01:01 haplotype associated with lamotrigine-induced maculopapular exanthema in Mexican Mestizo patients.
    Pharmacogenomics. 2014. Fricke-Galindo Ingrid, Martínez-Juárez Iris E, Monroy-Jaramillo Nancy, Jung-Cook Helgi, Falfán-Valencia Ramcés, Ortega-Vázquez Alberto, Alonso-Vilatela María Elisa and López-López Marisol.
    Pediatric
    Literature
    Gene-wide tagging study of the effects of common genetic polymorphisms in the alpha subunits of the GABA(A) receptor on epilepsy treatment response.
    Pharmacogenomics. 2013. Hung Chin-Chuan, Chen Pei-Lung, Huang Wan-Min, Tai John Jen, Hsieh Tsung-Jen, Ding Shih-Torng, Hsieh Yow-Wen and Liou Horng-Huei.
    Literature
    Predictive markers for carbamazepine and lamotrigine-induced maculopapular exanthema in Han Chinese.
    Epilepsy research. 2013. Li Li-Juan, Hu Fa-Yun, Wu Xin-Tong, An Dong-Mei, Yan Bo and Zhou Dong.
    Literature
    HLA-B alleles associated with severe cutaneous reactions to antiepileptic drugs in Han Chinese.
    Epilepsia. 2013. Cheung Ying-Kit, Cheng Suk-Hang, Chan Ernest J M, Lo Su V, Ng Margaret H L and Kwan Patrick.
    Pediatric
    Literature
    Impact of P-glycoprotein and breast cancer resistance protein on the brain distribution of antiepileptic drugs in knockout mouse models.
    European journal of pharmacology. 2013. Nakanishi Haruka, Yonezawa Atsushi, Matsubara Kazuo and Yano Ikuko.
    Literature
    Lamotrigine-induced hypersensitivity syndrome in a Han Chinese patient with the HLA-B 5801 genotype.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2013. Chow Julie Chi, Huang Chin-Wei, Fang Chen-Wen, Wu Yi-Jen and Tsai Jing-Jane.
    Literature
    Effect of lamotrigine on Na(v)1.4 voltage-gated sodium channels.
    Journal of pharmacological sciences. 2013. Nakatani Yoshihiko, Masuko Haruka and Amano Taku.
    Literature
    The transport of antiepileptic drugs by P-glycoprotein.
    Advanced drug delivery reviews. 2012. Zhang Chunbo, Kwan Patrick, Zuo Zhong and Baum Larry.
    Literature
    Genome-wide association study of serious blistering skin rash caused by drugs.
    The pharmacogenomics journal. 2012. Shen Y, Nicoletti P, Floratos A, Pirmohamed M, Molokhia M, Geppetti P, Benemei S, Giomi B, Schena D, Vultaggio A, Stern R, Daly M J, John S, Nelson M R, Pe'er I and International Serious Adverse Events Consortium (SAEC).
    Literature
    Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions.
    Pharmacogenomics. 2012. McCormack Mark, Urban Thomas J, Shianna Kevin V, Walley Nicole, Pandolfo Massimo, Depondt Chantal, Chaila Elijah, O'Conner Gerard D, Kasperavičiūtė Dalia, Radtke Rodney A, Heinzen Erin L, Sisodiya Sanjay M, Delanty Norman and Cavalleri Gianpiero L.
    Literature
    Lamotrigine is a substrate for OCT1 in brain endothelial cells.
    Biochemical pharmacology. 2012. Dickens David, Owen Andrew, Alfirevic Ana, Giannoudis Athina, Davies Andrea, Weksler Babette, Romero Ignacio A, Couraud Pierre-Olivier and Pirmohamed Munir.
    Literature
    Lack of association between ABCC2 gene variants and treatment response in epilepsy.
    Pharmacogenomics. 2012. Hilger Eva, Reinthaler Eva Maria, Stogmann Elisabeth, Hotzy Christoph, Pataraia Ekaterina, Baumgartner Christoph, Zimprich Alexander and Zimprich Fritz.
    Literature
    Functional analysis of UGT1A4(P24T) and UGT1A4(L48V) variant enzymes.
    Pharmacogenomics. 2011. Zhou Jin, Argikar Upendra A and Remmel Rory P.
    Literature
    Hla-B alleles and lamotrigine-induced cutaneous adverse drug reactions in the Han Chinese population.
    Basic & clinical pharmacology & toxicology. 2011. Shi Yi-Wu, Min Fu-Li, Liu Xiao-Rong, Zan Li-Xuan, Gao Mei-Mei, Yu Mei-Juan and Liao Wei-Ping.
    Pediatric
    Literature
    SCN1A splice variants exhibit divergent sensitivity to commonly used antiepileptic drugs.
    Epilepsia. 2011. Thompson Christopher H, Kahlig Kristopher M and George Alfred L.
    Literature
    Gene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy.
    Pharmacogenomics. 2011. Kwan Patrick, Wong Virginia, Ng Ping Wing, Lui Colin Hiu Tung, Sin Ngai Chuen, Wong Ka Sing and Baum Larry.
    Pediatric
    Literature
    Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein).
    Pharmacogenetics and genomics. 2011. Hodges Laura M, Markova Svetlana M, Chinn Leslie W, Gow Jason M, Kroetz Deanna L, Klein Teri E and Altman Russ B.
    Literature
    Association study of lamotrigine-induced cutaneous adverse reactions and HLA-B*1502 in a Han Chinese population.
    Epilepsy research. 2010. An Dong-Mei, Wu Xin-Tong, Hu Fa-Yun, Yan Bo, Stefan Hermann and Zhou Dong.
    Pediatric
    Literature
    Identifying genomic and developmental causes of adverse drug reactions in children.
    Pharmacogenomics. 2010. Becker Mara L and Leeder J Steven.
    Pediatric
    Literature
    Transporter hypothesis of drug-resistant epilepsy: challenges for pharmacogenetic approaches.
    Pharmacogenomics. 2010. Potschka Heidrun.
    Literature
    Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese.
    Pharmacogenomics. 2010. Hung Shuen-Iu, Chung Wen-Hung, Liu Zhi-Sheng, Chen Chien-Hsiun, Hsih Mo-Song, Hui Rosaline Chung-yee, Chu Chia-Yu and Chen Yuan-Tsong.
    Pediatric
    Literature
    Bioactivation of lamotrigine in vivo in rat and in vitro in human liver microsomes, hepatocytes, and epidermal keratinocytes: characterization of thioether conjugates by liquid chromatography/mass spectrometry and high field nuclear magnetic resonance spectroscopy.
    Chemical research in toxicology. 2010. Chen Hao, Grover Scott, Yu Linning, Walker Gregory and Mutlib Abdul.
    Literature
    Key factors in the discovery and development of new antiepileptic drugs.
    Nature reviews. Drug discovery. 2010. Bialer Meir and White H Steve.
    Literature
    Studies on induction of lamotrigine metabolism in transgenic UGT1 mice.
    Xenobiotica; the fate of foreign compounds in biological systems. 2009. Argikar U A, Senekeo-Effenberger K, Larson E E, Tukey R H and Remmel R P.
    Literature
    High-resolution HLA genotyping and severe cutaneous adverse reactions in lamotrigine-treated patients.
    Pharmacogenetics and genomics. 2009. Kazeem Gbenga R, Cox Charles, Aponte Jennifer, Messenheimer John, Brazell Celia, Nelsen Andrew C, Nelson Matthew R and Foot Elizabeth.
    Pediatric
    Literature
    Gene-wide tagging study of association between ABCB1 polymorphisms and multidrug resistance in epilepsy in Han Chinese.
    Pharmacogenomics. 2009. Kwan Patrick, Wong Virginia, Ng Ping Wing, Lui Colin Hiu Tung, Sin Ngai Chuen, Poon Wai Sang, Ng Ho Keung, Wong Ka Sing and Baum Larry.
    Pediatric
    Literature
    Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy.
    Pharmacogenetics and genomics. 2009. Ufer Mike, Mosyagin Igor, Muhle Hiltrud, Jacobsen Thies, Haenisch Sierk, Häsler Robert, Faltraco Frank, Remmler Cornelia, von Spiczak Sarah, Kroemer Heyo K, Runge Uwe, Boor Rainer, Stephani Ulrich and Cascorbi Ingolf.
    Pediatric
    Literature
    Variation in glucuronidation of lamotrigine in human liver microsomes.
    Xenobiotica; the fate of foreign compounds in biological systems. 2009. Argikar U A and Remmel R P.
    Pediatric
    Literature
    A case with Stevens Johnson syndrome triggered by combination of clobazam, lamotrigine, and valproic acid treatment.
    International journal of dermatology. 2009. Ertam Ilgen, Sezgin Aycan Ozden and Unal Idil.
    Literature
    Several major antiepileptic drugs are substrates for human P-glycoprotein.
    Neuropharmacology. 2008. Luna-Tortós Carlos, Fedrowitz Maren and Löscher Wolfgang.
    Literature
    Exploring the possible interaction between anti-epilepsy drugs and multidrug efflux pumps; in vitro observations.
    European journal of pharmacology. 2008. Rivers Francesca, O'Brien Terence J and Callaghan Richard.
    Literature
    Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs.
    Pharmacogenetics and genomics. 2008. Hung Chin-Chuan, Chen Chih-Chuan, Lin Chun-Jung and Liou Horng-Huei.
    Literature
    A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs.
    Pharmacogenetics and genomics. 2008. Lonjou Christine, Borot Nicolas, Sekula Peggy, Ledger Neil, Thomas Laure, Halevy Sima, Naldi Luigi, Bouwes-Bavinck Jan-Nico, Sidoroff Alexis, de Toma Claudia, Schumacher Martin, Roujeau Jean-Claude, Hovnanian Alain, Mockenhaupt Maja and RegiSCAR study group.
    Literature
    Stevens-Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs. The EuroSCAR-study.
    The Journal of investigative dermatology. 2008. Mockenhaupt Maja, Viboud Cecile, Dunant Ariane, Naldi Luigi, Halevy Sima, Bouwes Bavinck Jan Nico, Sidoroff Alexis, Schneck Jürgen, Roujeau Jean-Claude and Flahault Antoine.
    Literature
    Comparison and predictors of rash associated with 15 antiepileptic drugs.
    Neurology. 2007. Arif H, Buchsbaum R, Weintraub D, Koyfman S, Salas-Humara C, Bazil C W, Resor S R and Hirsch L J.
    Literature
    In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interaction.
    Drug metabolism and disposition: the biological fate of chemicals. 2006. Rowland Andrew, Elliot David J, Williams J Andrew, Mackenzie Peter I, Dickinson Ronald G and Miners John O.
    Literature
    Lack of interactions between breast cancer resistance protein (bcrp/abcg2) and selected antiepileptic agents.
    Epilepsia. 2006. Cerveny Lukas, Pavek Petr, Malakova Jana, Staud Frantisek and Fendrich Zdenek.
    Literature
    Defining the clinical role of pharmacogenetics in antiepileptic drug therapy.
    The pharmacogenomics journal. 2006. Dlugos D J, Buono R J and Ferraro T N.
    Literature
    Med-psych drug-drug interactions update.
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