mifepristone

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Literature

The publications shown below are associated with this chemical in PharmGKB based on (1) literature annotations, (2) variant annotations, (3) VIP summaries, or (4) pathways.

    12 items
    Literature
    Impact of mifepristone, a glucocorticoid/progesterone antagonist, on HDL cholesterol, HDL particle concentration, and HDL function.
    The Journal of clinical endocrinology and metabolism. 2012. Page Stephanie T, Krauss Ronald M, Gross Coleman, Ishida Brian, Heinecke Jay W, Tang Chongren, Amory John K, Schaefer Peter M, Cox Cheryl J, Kane John, Purnell Jonathan Q, Weinstein Richard L and Vaisar Tomáš.
    Literature
    Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3.
    European journal of pharmacology. 2008. Gui Chunshan, Miao Yi, Thompson Lucas, Wahlgren Bret, Mock Melissa, Stieger Bruno and Hagenbuch Bruno.
    Literature
    Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers.
    The Journal of pharmacology and experimental therapeutics. 2007. Faucette Stephanie R, Zhang Tong-Cun, Moore Rick, Sueyoshi Tatsuya, Omiecinski Curtis J, LeCluyse Edward L, Negishi Masahiko and Wang Hongbing.
    Literature
    Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist.
    Science (New York, N.Y.). 2006. Poole Aleksandra Jovanovic, Li Ying, Kim Yoon, Lin Suh-Chin J, Lee Wen-Hwa and Lee Eva Y-H P.
    Literature
    Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions.
    Current drug metabolism. 2006. Sinz Michael, Kim Sean, Zhu Zhengrong, Chen Taosheng, Anthony Monique, Dickinson Kenneth and Rodrigues A David.
    Literature
    The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR).
    The Journal of biological chemistry. 2004. Burk Oliver, Koch Ina, Raucy Judy, Hustert Elisabeth, Eichelbaum Michel, Brockmöller Jürgen, Zanger Ulrich M and Wojnowski Leszek.
    Literature
    A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system.
    The Journal of pharmacology and experimental therapeutics. 2002. Raucy Judy, Warfe Lyndon, Yueh Mei-Fei and Allen Scott W.
    Literature
    Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.
    The Journal of biological chemistry. 2000. Moore L B, Parks D J, Jones S A, Bledsoe R K, Consler T G, Stimmel J B, Goodwin B, Liddle C, Blanchard S G, Willson T M, Collins J L and Kliewer S A.
    Literature
    The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.
    Molecular endocrinology (Baltimore, Md.). 2000. Jones S A, Moore L B, Shenk J L, Wisely G B, Hamilton G A, McKee D D, Tomkinson N C, LeCluyse E L, Lambert M H, Willson T M, Kliewer S A and Moore J T.
    Literature
    Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction.
    Proceedings of the National Academy of Sciences of the United States of America. 1998. Bertilsson G, Heidrich J, Svensson K, Asman M, Jendeberg L, Sydow-Bäckman M, Ohlsson R, Postlind H, Blomquist P and Berkenstam A.
    Literature
    The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.
    The Journal of clinical investigation. 1998. Lehmann J M, McKee D D, Watson M A, Willson T M, Moore J T and Kliewer S A.
    Literature
    Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors.
    Drug metabolism reviews. 1997. Rendic S and Di Carlo F J.