ERBB2
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ERBB2, also known as HER2, is an important diagnostic pharmacogene for cancer PGx. Many consider it the poster-child for the co-development of a targeted drug (trastuzumab) and companion diagnostic testing (for HER2 amplification/overexpression)[Article:9788323].
Location
| Strand | Plus |
| Cytogenetic | chr17 : q21.1 - q12 |
| GRCh37 | chr17 : 37844167 - 37884915 |
| GRCh38 | chr17 : 39688084 - 39728662 |
Names & Symbols
PharmGKB ID
HGNC Approved Name
Alternate Names
- human epidermal growth factor receptor 2
- metastatic lymph node gene 19
- neuro/glioblastoma derived oncogene homolog
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Alternate Symbols
- CD340
- HER-2
- HER2
- MLN-19
- NEU
- NGL
- c-ERB-2
- c-ERB2
- p185(erbB2)