What is PharmGKB?

PharmGKB is an NIH-funded resource that provides information about how human genetic variation affects response to medications. PharmGKB collects, curates and disseminates knowledge about clinically actionable gene-drug associations and genotype-phenotype relationships. When using PharmGKB, you will see different types of information. These are detailed in the sections below.
Prescribing Information
Drug Label Annotations
Genotype Selection Interface
Curated Pathways
Clinical Annotations
Variant Annotations
Focus
Resources
VIPs
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Prescribing Information

Prescribing information includes clinical guidelines for how to adjust prescription of certain medications based on a person's genetic information. Several organizations around the world write these guidelines, and PharmGKB provides annotations of them on our website.

Some organizations provide specific guidelines on how to use a person's genetic information to help select a medication or adjust the dose of a medication. PharmGKB provides annotations of clinical guidelines written by the Clinical Pharmacogenetic Implementation Consortium (CPIC)(opens in new window), the Dutch Pharmacogenetics Working Group (DPWG)(opens in new window), and other professional societies including the Canadian Pharmacogenomics Network for Drug Safety (CPNDS) and the French National Network of Pharmacogenetics (RNPGx). The CPIC guidelines are created in collaboration with PharmGKB.

Where applicable, guideline annotations are tagged with the Alternate DrugLearn more about the Alternate Drug tag(opens in new window),Dosing InfoLearn more about the Dosing Info tag(opens in new window) orOther GuidanceLearn more about the Other Guidance tag(opens in new window) tags(opens in new window) to give an overview of the type of recommendation given in the guideline. Annotations of CPIC and DPWG guidelines feature an interactive genotype(opens in new window) picker. Users can enter a genotype of interest and see the guideline recommendations specific to that genotype.

Some drug labels from regulators (e.g. FDA, EMA, HCSC) also contain pharmacogenomic prescribing information. This information is displayed in the Prescribing section of PharmGKB drug label annotations and in the Prescribing Info section on pages for drugs, genes or variants. More information can be found under the Drug Label Annotations tab on this page.