What is PharmGKB?

PharmGKB is an NIH-funded resource that provides information about how human genetic variation affects response to medications. PharmGKB collects, curates and disseminates knowledge about clinically actionable gene-drug associations and genotype-phenotype relationships. When using PharmGKB, you will see different types of information. These are detailed in the sections below.

First time? Consider first taking a short guided clicking tour(opens in new window) through PharmGKB to get a feel for the website, and then quickly reading about how to search PharmGKB(opens in new window).

PharmGKB also has training exercises available to help new users find their way around the website. Note that these exercises are not to be used for credit, including professional development such as CME.

Download training exercises

Prescribing Information

Drug Label Annotations

Genotype Selection Interface

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Resources

The PharmGKB Resources are curated collections of information centered around a chosen topic. This can range from pharmacogenomics knowledge relevant to certain clinical areas (e.g. cancer, addiction) to lists of internal and external educational resources in PGx and pharmacogenomics information from organizations including the U.S. Food and Drug Administration (FDA) and the Association for Molecular Pathology (AMP). PharmGKB Resources can be found under the Resources heading on the homepage and are listed below:

Cancer Pharmacogenetics(opens in new window) (collection of genes, drugs and pathways with pharmacogenetic information relevant to cancer)
PGx in Drug Use and Addiction(opens in new window) (collection of genes, drugs and pathways with pharmacogenetic information relevant to addiction)
Therapeutic Resource for COVID-19(opens in new window) (collection of genes, drugs and pathways with pharmacogenetic information relevant to the treatment of COVID-19 and impacts from the COVID-19 pandemic)
Gene Information Tables(opens in new window) (Information tables for genes found in CPIC guidelines. Includes allele definition, functionality and frequency tables)
FDA PGx Associations(opens in new window) (searchable, sortable list of the information contained in the FDA Table of Pharmacogenetic Associations)
Drugs with Prescribing Information(opens in new window) (curated drugs in PharmGKB with prescribing information available from a clinical guideline annotation, annotated drug label or from the FDA Table of Pharmacogenetic Associations)
AMP Recommendations(opens in new window) (Table displaying the AMP minimum sets of alleles for pharmacogenomic testing)
Biogeographical Groups for PGx(opens in new window) (Explanatory information about the PharmGKB biogeographical grouping system)
PGx Publication Tips(opens in new window) (advice on how to write scientific publications to ensure they can be easily curated into PharmGKB)
Educational Resources(opens in new window) (Links to educational resources in pharmacogenomics provided by PharmGKB and external organizations)